KD-Validated Drosha Ribonuclease III Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Drosha Ribonuclease III Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:DROSHA; Drosha Ribonuclease III; RNASE3L; RN3; HSA242976; RNASEN; Drosha, Double-Stranded RNA-Specific Endoribonuclease; Ribonuclease Type III, Nuclear; Ribonuclease 3; EC 3.1.26.3; RNase III; ETOHI2; P241; Putative Protein P241 Which Interacts With Transcription Factor Sp1; Drosha, Ribonuclease Type III; Putative Ribonuclease III; Nuclear RNase III Drosha; Ribonuclease III; Protein Drosha; RANSE3L; Etohi2 Background: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016] Research Area: Epigenetics and Nuclear Signaling