KD-Validated E2F Transcription Factor 1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated E2F Transcription Factor 1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:E2F1; E2F Transcription Factor 1; RBBP3; RBP3; Retinoblastoma-Binding Protein 3 (E2F-Like); Retinoblastoma-Associated Protein 1; Retinoblastoma-Binding Protein 3; Transcription Factor E2F1; PRB-Binding Protein E2F-1; RBAP-1; RBBP-3; E2F-1; PBR3; RBAP1 Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008] Research Area: Epigenetics and Nuclear Signaling,Cancer