KD-Validated EWS RNA Binding Protein 1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated EWS RNA Binding Protein 1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:EWSR1; EWS RNA Binding Protein 1; EWS; Ewing Sarcoma Breakpoint Region 1; RNA-Binding Protein EWS; Ewings Sarcoma EWS-Fli1 (Type 1) Oncogene; Ewing Sarcoma Breakpoint Region 1 Protein; EWS Oncogene; BK984G1.4; EWS-FLI1 Background: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009] Research Area: Tags & Cell Markers,Epigenetics and Nuclear Signaling