KD-Validated GCLC Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated GCLC Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:GCLC; Glutamate-Cysteine Ligase Catalytic Subunit; GLCLC; GLCL; GCS; Glutamate--Cysteine Ligase Catalytic Subunit; Gamma-Glutamylcysteine Synthetase; GCS Heavy Chain; EC 6.3.2.2; Gamma-ECS; Glutamate-Cysteine Ligase, Catalytic Subunit; GCL Background: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010] Research Area: Signal Transduction,Cell Biology,Metabolism