KD-Validated Granulin Precursor Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Granulin Precursor Mouse Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2,500; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:GRN; Granulin Precursor; PCDGF; PGRN; Progranulin; CLN11; PC Cell-Derived Growth Factor; Glycoprotein Of 88 Kda; Glycoprotein 88; Proepithelin; Acrogranin; GP88; PEPI; Epithelin Precursor; Granulin-Epithelin; Epithelin; Granulins; GEP Background: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] Research Area: Neuroscience,Immunology,Cancer