KD-Validated HIF 1 Beta Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated HIF 1 Beta Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:ARNT; Aryl Hydrocarbon Receptor Nuclear Translocator ; BHLHe2; HIF-1beta; Class E Basic Helix-Loop-Helix Protein 2; Hypoxia Inducible Factor 1; Subunit Beta; Dioxin Receptor, Nuclear Translocator; HIF-1-Beta; HIF1-Beta; ARNT1; Hypoxia-Inducible Factor 1, Beta Subunit; Hypoxia-Inducible Factor 1-Beta; ARNT Protein; HIF1BETA; BHLHE2; HIF1B; TANGO Background: This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] Research Area: Cardiovascular,Epigenetics and Nuclear Signaling,Cancer,Metabolism