KD-Validated IGF2R Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated IGF2R Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,M and is suitable for WB,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:4,000-1:20,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:IGF2R; Insulin Like Growth Factor 2 Receptor; MPRI; CI-M6PR; CI-MPR; MPR300; CD222; CIMPR; M6P-R; MPR1; Cation-Independent Mannose-6-Phosphate Receptor; Insulin-Like Growth Factor II Receptor; Insulin-Like Growth Factor 2 Receptor; 300 KDa Mannose 6-Phosphate Receptor; CI Man-6-P Receptor; M6P/IGF2 Receptor; IGF-II Receptor; M6P/IGF2R; MPR 300; Cation-Independent Mannose-6 Phosphate Receptor; CD222 Antigen; M6PR Background: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015] Research Area: Immunology,Tags & Cell Markers,Signal Transduction,Neuroscience