KD-Validated Karyopherin Subunit Alpha 2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Karyopherin Subunit Alpha 2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:KPNA2; Karyopherin Subunit Alpha 2; SRP1alpha; PTAC58; IPOA1; QIP2; RCH1; Karyopherin Alpha 2 (RAG Cohort 1, Importin Alpha 1); Nuclear Pore-Targeting Complex 58kD Component; Importin Subunit Alpha-1; RAG Cohort Protein 1; SRP1-Alpha; Karyopherin Subunit Alpha-2; Importin Subunit Alpha-2; Karyopherin Alpha 2; Importin-Alpha-P1; Importin Alpha 1; RAG Cohort 1; Pendulin; SRP1 Background: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] Research Area: Immunology,Signal Transduction