KD-Validated KDM2A Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated KDM2A Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:100-1:1,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:KDM2A; Lysine Demethylase 2A; JHDM1A; FBL11; CXXC8; FBL7; F-Box And Leucine-Rich Repeat Protein 11; KIAA1004; LILINA; FBXL11; JmjC Domain-Containing Histone Demethylation Protein 1A; Jumonji C Domain-Containing Histone Demethylase 1A; [Histone-H3]-Lysine-36 Demethylase 1A; Lysine (K)-Specific Demethylase 2A; CXXC-Type Zinc Finger Protein 8; Lysine-Specific Demethylase 2A; F-Box/LRR-Repeat Protein 11; DKFZP434M1735; EC 1.14.11.27; FLJ00115; F-Box Protein Lilina; F-Box Protein FBL11; F-Box Protein FBL7 Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] Research Area: Epigenetics and Nuclear Signaling