KD-Validated Lamin A/C Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Lamin A/C Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2,500; FC 1:200-1:2,000 Alternative Names of Immunogen:LMNA; Lamin A/C; HGPS; MADA; LMN1; Mandibuloacral Dysplasia Type A; Lamin A/C-Like 1; Prelamin-A/C; Progerin; LGMD1B; CMD1A; LMNL1; PRO1; Limb Girdle Muscular Dystrophy 1B (Autosomal Dominant); Cardiomyopathy, Dilated 1A (Autosomal Dominant); Epididymis Secretory Sperm Binding Protein; Progeria 1 (Hutchinson-Gilford Type); Renal Carcinoma Antigen NY-REN-32; 70 KDa Lamin; Lamin C; CMT2B1; CDCD1; FPLD2; Lamin; CDDC; EMD2; FPLD; LDP1; LMNC; FPL; IDC; LFP Background: The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, May 2022] Research Area: Tags & Cell Markers,Signal Transduction