KD-Validated LEFTY1 + LEFTY2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated LEFTY1 + LEFTY2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:LEFTY1; Left-Right Determination Factor 1; LEFTYB; LEFTB; Left-Right Determination Factor B; Protein Lefty-1; Protein Lefty-B; Left-Right Determination, Factor B; LEFTY2; Left-Right Determination Factor 2; LEFTYA; LEFTA; TGFB4; EBAF; Endometrial Bleeding-Associated Factor; Left-Right Determination Factor A; Transforming Growth Factor Beta-4; Protein Lefty-2; Protein Lefty-A; TGF-Beta-4; Endometrial Bleeding Associated Factor (Left-Right Determination, Factor A; Transforming Growth Factor Beta Superfamily); Transforming Growth Factor, Beta-4 (Endometrial Bleeding-Associated Factor; LEFTY A) Background: LEFTY1: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016] LEFTY2: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016] Research Area: Signal Transduction,Stem Cells,Cancer