KD-Validated Legumain Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Legumain Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,M and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:LGMN; Legumain; LGMN1; PRSC1; Protease, Cysteine, 1 (Legumain) ; Asparaginyl Endopeptidase; Protease, Cysteine 1; EC 3.4.22.34; Cysteine Protease 1; AEP Background: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008] Research Area: Immunology,Signal Transduction,Cell Biology,Cancer,Metabolism