KD-Validated MAP2K3 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated MAP2K3 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:MAP2K3; Mitogen-Activated Protein Kinase Kinase 3; MEK3; MKK3; Stress-Activated Protein Kinase Kinase 2; MAP Kinase Kinase 3; MAPK/ERK Kinase 3; MAPKK3; SAPKK2; PRKMK3; Dual Specificity Mitogen-Activated Protein Kinase Kinase 3; SAPK Kinase 2; EC 2.7.12.2; SAPKK-2; MAPKK 3; MEK 3; Dual Specificity Mitogen Activated Protein Kinase Kinase 3; SKK2 Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] Research Area: Signal Transduction,Epigenetics and Nuclear Signaling,Cancer,Immunology