KD-Validated MCM6 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated MCM6 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:MCM6; Minichromosome Maintenance Complex Component 6; Minichromosome Maintenance Deficient (Mis5, S. Pombe) 6; DNA Replication Licensing Factor MCM6; P105MCM; Mis5; MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) (S. Cerevisiae); MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe); Minichromosome Maintenance Deficient 6 Homolog (S. Cerevisiae); MIS5 Homolog (S.Pombe); EC 3.6.4.12; MCG40308; MIS5 Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012] Research Area: Epigenetics and Nuclear Signaling,Epigenetics and Nuclear Signaling