KD-Validated Melanocortin 1 Receptor Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Melanocortin 1 Receptor Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000 Alternative Names of Immunogen:MC1R; Melanocortin 1 Receptor; MSH-R; Alpha Melanocyte Stimulating Hormone Receptor; Melanocyte-Stimulating Hormone Receptor; MC1-R; Melanocortin 1 Receptor (Alpha Melanocyte Stimulating Hormone Receptor); Melanocortin Receptor 1; Melanotropin Receptor; SHEP2; CMM5; MSHR Background: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008] Research Area: Neuroscience,Metabolism