KD-Validated Methyl-CpG Binding Domain Protein 2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Methyl-CpG Binding Domain Protein 2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:2,000-1:10,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:MBD2; Methyl-CpG Binding Domain Protein 2; Methyl-CpG-Binding Domain Protein 2; Demethylase; DMTase; Methyl-CpG-Binding Protein MBD2; NY-CO-41 Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Research Area: Epigenetics and Nuclear Signaling