KD-Validated Mevalonate Kinase Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Mevalonate Kinase Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Rat and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:Mevalonate Kinase; MK; LRBP; LH Receptor MRNA-Binding Protein; EC 2.7.1.36; Mevalonate Kinase (Mevalonic Aciduria); Mevalonate Kinase 1; Mevalonic Aciduria; POROK3; MVLK Background: This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] Research Area: Cardiovascular,Signal Transduction,Cancer,Metabolism