KD-Validated NEDD4L Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated NEDD4L Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:4,000-1:20,000; FC 1:200-1:2,000 Alternative Names of Immunogen:NEDD4L; NEDD4 Like E3 Ubiquitin Protein Ligase; KIAA0439; NEDD4-2; RSP5; Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like, E3 Ubiquitin Protein Ligase; HECT-Type E3 Ubiquitin Transferase NED4L; E3 Ubiquitin-Protein Ligase NEDD4-Like; NEDD4.2; Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like; Ubiquitin-Protein Ligase Rsp5; EC 2.3.2.26; EC 2.3.2.36; HNEDD4-2; EC 6.3.2; Nedd4-2; PVNH7; NEDL3 Background: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] Research Area: Epigenetics and Nuclear Signaling,Cell Biology