KD-Validated PDCD6IP Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated PDCD6IP Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000 Alternative Names of Immunogen:PDCD6IP; Programmed Cell Death 6 Interacting Protein; AIP1; Hp95; Programmed Cell Death 6-Interacting Protein; Alix; ALG-2 Interacting Protein X; PDCD6-Interacting Protein; Apoptosis-Linked Gene 2-Interacting Protein X; Dopamine Receptor Interacting Protein 4; ALG-2 Interacting Protein X; ALG-2 Interacting Protein 1; ALG-2-Interacting Protein 1; KIAA1375; MCPH29; DRIP4; ALIX Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012] Research Area: Cell Biology,Microbiology,Signal Transduction