KD-Validated PFKFB3 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated PFKFB3 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:PFKFB3; 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3; 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme 3; Renal Carcinoma Antigen NY-REN-56; 6PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; IPFK-2; Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase; Fructose-6-Phosphate,2-Kinase/Fructose-2, 6-Bisphosphatase; 6-Phosphofructo-2-Kinase/ Fructose-2,6-Bisphosphatase; IPFK2; PFK2 Background: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016] Research Area: Cardiovascular,Signal Transduction,Neuroscience,Cancer,Metabolism