KD-Validated Phospho-eIF2 Alpha (Ser51) Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Phospho-eIF2 Alpha (Ser51) Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:EIF2S1; Eukaryotic Translation Initiation Factor 2 Subunit Alpha; EIF-2alpha; EIF2A; Eukaryotic Translation Initiation Factor 2, Subunit 1 Alpha, 35kDa; Eukaryotic Translation Initiation Factor 2 Subunit 1; EIF-2-Alpha; EIF2-Alpha; EIF-2A; EIF2; Eukaryotic Translation Initiation Factor 2, Subunit 1 (Alpha, 35kD ); EIF-2 Background: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010] Research Area: Epigenetics and Nuclear Signaling