KD-Validated Phospho-Presenilin 1 (Ser310) Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Phospho-Presenilin 1 (Ser310) Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:PSEN1; Presenilin 1; PSNL1; PS-1; PS1; S182; FAD; AD3; Familial Alzheimer Disease; Presenilin-1; Alzheimer Disease 3; Protein S182; EC 3.4.23.-; EC 3.4.23; ACNINV3 Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] Research Area: Neuroscience,Cancer,Metabolism