KD-Validated Phospholipase C Gamma 1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Phospholipase C Gamma 1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:PLCG1; Phospholipase C Gamma 1; PLC-II 2; PLC148; NCKAP3; PLC1; 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1; Phospholipase C, Gamma 1 (Formerly Subtype 148); Phosphoinositide Phospholipase C-Gamma-1; Phospholipase C-II ; PLC-Gamma-1; EC 3.1.4.11; PLCgamma1; PLC-148; 1-Phosphatidyl-D-Myo-Inositol-4,5-Bisphosphate; Monophosphatidylinositol Phosphodiesterase; Triphosphoinositide Phosphodiesterase; Phosphatidylinositol Phospholipase ; Phosphoinositide Phospholipase C; Inositoltrisphosphohydrolase; Phospholipase C, Gamma 1; Phospholipase C-Gamma-1; Phosphoinositidase C; Phospholipase C-148; PLCGAMMA1 Background: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Research Area: Cardiovascular,Signal Transduction,Cancer,Metabolism