KD-Validated PKN1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated PKN1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000 Alternative Names of Immunogen:PKN1; Protein Kinase N1; PRK1; PAK1; PKN; Protein Kinase C-Like 1; PRKCL1; DBK; Serine/Threonine-Protein Kinase N1; Protease-Activated Kinase 1; Protein Kinase C-Like PKN; Protein Kinase PKN-Alpha; EC 2.7.11.13; MGC46204; PAK-1; Protein Kinase C-Related Kinase 1; Serine/Threonine Protein Kinase N; Protein-Kinase C-Related Kinase 1; Serine-Threonine Protein Kinase N; Serine-Threonine Kinase N; PKN-ALPHA; EC 2.7.11 Background: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Research Area: Signal Transduction,Epigenetics and Nuclear Signaling