KD-Validated Poly(A) Binding Protein Nuclear 1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Poly(A) Binding Protein Nuclear 1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:PABPN1; Poly(A) Binding Protein Nuclear 1; PAB2 ; PABP2; Polyadenylate-Binding Protein 2; PABP-2; PABII; OPMD; Polyadenylate-Binding Nuclear Protein 1; Poly(A)-Binding Protein, Nuclear 1; Poly(A) Binding Protein, Nuclear 1; Nuclear Poly(A)-Binding Protein 1; Poly(A) Binding Protein II; Poly(A)-Binding Protein II; Poly(A) Binding Protein 2; Poly(A)-Binding Protein 2 Background: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010] Research Area: Epigenetics and Nuclear Signaling