KD-Validated Pro-Apoptotic WT1 Regulator Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Pro-Apoptotic WT1 Regulator Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:PAWR; Pro-Apoptotic WT1 Regulator; Par-4; PAR4; PRKC Apoptosis WT1 Regulator Protein; PRKC, Apoptosis, WT1, Regulator; Prostate Apoptosis Response-4; Prostate Apoptosis Response Protein PAR-4; Prostate Apoptosis Response Protein 4; Prostate Apoptosis Response 4 Protein; Transcriptional Repressor PAR4; WT1-Interacting Protein Background: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017] Research Area: Cell Biology,Epigenetics and Nuclear Signaling,Metabolism,Cancer