KD-Validated Prosaposin Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Prosaposin Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000 Alternative Names of Immunogen:PSAP; Prosaposin; GLBA; SAP1; Sphingolipid Activator Protein-1; Sphingolipid Activator Protein-2; Proactivator Polypeptide; Precursor Of Saposins; Saposin-A; Saposin-B; Saposin-C; Saposin-D; SAP2; Variant Gaucher Disease And Variant Metachromatic Leukodystrophy; PARK24; PSAPD Background: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] Research Area: Signal Transduction,Metabolism