KD-Validated PTTG1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated PTTG1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,M and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:PTTG1 Regulator Of Sister Chromatid Separation, Securin; Securin; HPTTG; PTTG; EAP1; Tumor-Transforming Protein ; ECRAR; TUTR1; Endogenous Cardiac Regeneration-Associated Regulator; Pituitary Tumor-Transforming Gene 1 Protein; Pituitary Tumor-Transforming 1; ESP1-Associated Protein 1; Esp1-Associated Protein Background: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] Research Area: Cell Biology,Epigenetics and Nuclear Signaling,Cancer