KD-Validated RAD17 Rabbit Polyclonal Antibody

Description

EnkiLife offers the KD-Validated RAD17 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2,500 Alternative Names of Immunogen:RAD17; RAD17 Checkpoint Clamp Loader Component; RAD17Sp; Rad24; CCYC; Cell Cycle Checkpoint Protein RAD17; R24L; Cell Cycle Checkpoint Protein (RAD17); RAD17 Homolog (S. Pombe); RF-C Activator 1 Homolog; RF-C/Activator 1 Homolog; RAD1 (S. Pombe) Homolog; Rad17-Like Protein; RAD17 Homolog; RAD1 Homolog; HRAD17; HRad17 Background: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013] Research Area: Epigenetics and Nuclear Signaling