KD-Validated ROCK1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated ROCK1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:ROCK1; Rho Associated Coiled-Coil Containing Protein Kinase 1; P160ROCK; Renal Carcinoma Antigen NY-REN-35; Rho-Associated Protein Kinase 1; P160 ROCK-1; EC 2.7.11.1; ROCK-I; Rho-Associated, Coiled-Coil-Containing Protein Kinase 1; Rho-Associated, Coiled-Coil-Containing Protein Kinase I; EC 2.7.11 Background: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015] Research Area: Signal Transduction,Cell Biology,Cancer