KD-Validated Sad1 And UNC84 Domain Containing 2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Sad1 And UNC84 Domain Containing 2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:SUN2; Sad1 And UNC84 Domain Containing 2; UNC84B; SUN Domain-Containing Protein 2; Sad1/Unc-84 Protein-Like 2; Protein Unc-84 Homolog B; Rab5-Interacting Protein; Rab5IP; Unc-84 Homolog B (C. Elegans); Sad1 Unc-84 Domain Protein 2; Nuclear Envelope Protein; Unc-84 Homolog B; KIAA0668; RAB5IP; FRIGG Background: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010] Research Area: Tags & Cell Markers,Signal Transduction