KD-Validated Scaffold Attachment Factor B Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Scaffold Attachment Factor B Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:SAFB; Scaffold Attachment Factor B; SAFB1; HET; HSP27 Estrogen Response Element-TATA Box-Binding Protein; Hsp27 ERE-TATA Binding Protein; HSP27 ERE-TATA-Binding Protein; Scaffold Attachment Factor B1; SAF-B1; SAF-B; HAP; Heat-Shock Protein (HSP27) Estrogen Response Element And TATA Box-Binding Protein; Glutathione S-Transferase Fusion Protein; SAB-B1 Background: This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] Research Area: Epigenetics and Nuclear Signaling