KD-Validated Sequestosome 1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Sequestosome 1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:2,000-1:10,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:SQSTM1; Sequestosome 1; P60; P62B; A170; OSIL; P62; Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 KDa; EBI3-Associated Protein Of 60 KDa; Oxidative Stress Induced Like; Ubiquitin-Binding Protein P62; Autophagy Receptor P62; Sequestosome-1; EBIAP; PDB3; Phosphotyrosine Independent Ligand For The Lck SH2 Domain P62; EBI3-Associated Protein P60; Paget Disease Of Bone 3; FTDALS3; NADGP; DMRV; ZIP3; ORCA Background: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009] Research Area: Signal Transduction,Epigenetics and Nuclear Signaling,Cardiovascular,Metabolism,Cancer