KD-Validated SMC1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated SMC1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:SMC1A; Structural Maintenance Of Chromosomes 1A; DXS423E; SB1.8; KIAA0178; SMC1L1; Smcb; SMC1 (Structural Maintenance Of Chromosomes 1, Yeast)-Like 1; Structural Maintenance Of Chromosomes Protein 1A; SMC Protein 1A; SMC-1-Alpha; SMC1; SMC1 Structural Maintenance Of Chromosomes 1-Like 1 (Yeast); Epididymis Secretory Sperm Binding Protein; Segregation Of Mitotic Chromosomes 1; SMC1alpha; EIEE85; SMC-1A; CDLS2; DEE85; Sb1.8 Background: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] Research Area: Cell Biology,Epigenetics and Nuclear Signaling