KD-Validated TCEB2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated TCEB2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:ELOB; Elongin B; TCEB2; SIII; Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B); RNA Polymerase II Transcription Factor SIII Subunit B; Transcription Elongation Factor B Polypeptide; Transcription Elongation Factor B Subunit 2; Elongin 18 KDa Subunit; Elongin-B; SIII P18; RNA Polymerase II Transcription Factor SIII P18 Subunit; Epididymis Secretory Sperm Binding Protein; Elongin, 18-KD Subunit; EloB Background: This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008] Research Area: Epigenetics and Nuclear Signaling