KD-Validated TFE3 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated TFE3 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:TFE3; Transcription Factor Binding To IGHM Enhancer 3; BHLHe33; TFEA; Class E Basic Helix-Loop-Helix Protein 33; Transcription Factor E3; Transcription Factor For Immunoglobulin Heavy-Chain Enhancer 3; Transcription Factor E Family, Member A; Transcription Factor For IgH Enhancer; BHLHE33; MRXSPF; RCCP2; RCCX1 Background: This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Research Area: Immunology,Epigenetics and Nuclear Signaling