KD-Validated Thioredoxin Reductase 2 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KD-Validated Thioredoxin Reductase 2 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:TXNRD2; Thioredoxin Reductase 2; TRXR2; Selenoprotein Z; SELZ; TR3; TR; Thioredoxin Reductase 2, Mitochondrial; Thioredoxin Reductase Beta; Thioredoxin Reductase TR3; EC 1.8.1.9 4; TXNR2; Thioredoxin Reductase 3; KIAA1652; EC 1.8.1; TR-BETA; TR-Beta; GCCD5; SelZ Background: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017] Research Area: Cell Biology,Metabolism