KD-Validated TP53BP1 Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated TP53BP1 Mouse Monoclonal Antibody. This antibody reacts with Human,M and is suitable for WB,FCM,ICC,IHC-P application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2,500; FC 1:200-1:2,000; ICC 1:100-1:1,000; IHC-P 1:100-1:200 Alternative Names of Immunogen:TP53BP1; Tumor Protein P53 Binding Protein 1; 53BP1; TDRD30; P202; TP53-Binding Protein 1; P53-Binding Protein 1; P53BP1; Tumor Suppressor P53-Binding Protein 1; Tumor Protein P53-Binding Protein, 1; Tumor Protein 53-Binding Protein, 1 Background: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] Research Area: Epigenetics and Nuclear Signaling