KD-Validated UBE3A Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated UBE3A Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:400-1:2,000; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:UBE3A; Ubiquitin Protein Ligase E3A; EPVE6AP; HPVE6A; E6-AP; ANCR; AS; Human Papilloma Virus E6-Associated Protein; Human Papillomavirus E6-Associated Protein; Oncogenic Protein-Associated Protein E6-AP; HECT-Type Ubiquitin Transferase E3A; Renal Carcinoma Antigen NY-REN-54; E6AP Ubiquitin-Protein Ligase; Ubiquitin-Protein Ligase E3A; FLJ26981; CTCL Tumor Antigen Se37-2; Angelman Syndrome; EC 2.3.2.26; PIX1; E6AP Background: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Research Area: Epigenetics and Nuclear Signaling,Cell Biology,Neuroscience,Epigenetics and Nuclear Signaling