KD-Validated VRK1 Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated VRK1 Mouse Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM,ICC application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2,500; FC 1:200-1:2,000; ICC 1:100-1:1,000 Alternative Names of Immunogen:VRK1; VRK Serine/Threonine Kinase 1; Serine/Threonine-Protein Kinase VRK1; Vaccinia Related Kinase 1; EC 2.7.11.1; Vaccinia Virus B1R-Related Kinase 1; Vaccinia-Related Kinase 1; HMNR10; PCH1A; PCH1 Background: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008] Research Area: Cell Biology,Signal Transduction,Epigenetics and Nuclear Signaling