KD-Validated XIAP Mouse Monoclonal Antibody

Description

EnkiLife offers the KD-Validated XIAP Mouse Monoclonal Antibody. This antibody reacts with Human and is suitable for WB,FCM application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000; FC 1:200-1:2,000 Alternative Names of Immunogen:XIAP; X-Linked Inhibitor Of Apoptosis; BIRC4; HILP; API3; X-Linked Inhibitor Of Apoptosis, E3 Ubiquitin Protein Ligase; Baculoviral IAP Repeat-Containing Protein 4; RING-Type E3 Ubiquitin Transferase XIAP; E3 Ubiquitin-Protein Ligase XIAP; Inhibitor Of Apoptosis Protein 3; IAP-Like Protein 1; X-Linked IAP; HIAP-3; ILP-1; IAP-3; HIAP3; X-Linked Inhibitor Of Apoptosis Protein; Baculoviral IAP Repeat-Containing 4; IAP-Like Protein; EC 2.3.2.27; ILP1; MIHA; XLP2; IAP3; ILP Background: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] Research Area: Cell Biology,Cancer,Metabolism