KD014

Description

KD014 DX-2400 is a human monoclonal antibody mAb targeting MMP14 Ki: 0.9 nM . KD014 inhibits TGF? and SMAD2/3 activity, increases macrophage numbers and iNOS expression, and shifts macrophage phenotype toward anti-tumor M1-like. KD014 has anti-tumor activity in three different tumor models MDA-MB-231, MDA-MB-435, and PC3 . KD014 can be used in breast cancer research.