GENERAL CATALOGUE
Keap1-IN-1
HY-170301 · 50 mg
MedChemExpress · Cat: HY-170301
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medchemexpress.com/keap1-in-1.html
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Catalog No: HY-170301
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
Keap1-IN-1 Compound 27 is the inhibitor for Keap1, that covalently modifys the Cys151 site in the BTB domain of KEAP1, and interfers with the interaction between Keap-Nrf. Keap1-IN-1 upregulates the mRNA expression of the antioxidant stress element ARE -dependent gene NQO1 with an EC50 of 160 nM. Keap1-IN-1 exhibits cytotoxicity in cell U2OS with an EC50 of 527 nM.
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