GENERAL CATALOGUE
KI-DX-014
HY-175238 · 5 mg
MedChemExpress · Cat: HY-175238
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medchemexpress.com/ki-dx-014.htmlCatalog No: HY-175238
CAS No: 1309288-83-2
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
KI-DX-014 is a DDX21 inhibitor with an IC50 of 3.31 ??M. KI-DX-014 significantly inhibits the DDX21-RNA interaction and modulates ATPase activity and biomolecular condensate formation. KI-DX-014 reduces the DDX21-dependent release of P-TEFb from the 7SK snRNP complex, inhibits P-TEFb-dependent phosphorylation of the RNA polymerase II CTD, and induces developmental defects in zebrafish embryos. KI-DX-014 can be used for cancers and neurodegenerative disorders research.
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