GENERAL CATALOGUE
KI-TOX-A3
HY-176244 · 5 mg
MedChemExpress · Cat: HY-176244
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medchemexpress.com/ki-tox-a3.htmlCatalog No: HY-176244
CAS No: 1351116-34-1
Category: Epigenetics
Pack Size: 5 mg
Brand: MedChemExpress
Description
KI-TOX-A3 is a selective protein-protein interaction PPI inhibitor targeting TOX protein with an IC50 value of 0.51 ?M for TOX-KAT7 interaction . KI-TOX-A3 induces proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reversing CD8+ T cell exhaustion and inhibiting T-cell acute lymphoblastic leukemia T-ALL cell proliferation. KI-TOX-A3 is promising for research of hematological tumors e.g., T-ALL .
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