Ki11502

Description

Ki11502 is a multi-targeted receptor tyrosine kinase RTK inhibitor that selectively inhibits the activity of PDGF ?/? receptors with IC50 values less than 10 nM. Ki11502 selectively inhibits PDGF ? receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Ki11502 can induce Apoptosis and exhibits profound antiproliferative effects on select subsets of leukemia, including those with Imatinib HY-15463 resistant mutations. Ki11502 is highly suitable for studying the role of PDGF in vascular diseases, particularly the role of proteoglycans in atherosclerosis.