GENERAL CATALOGUE
KL-50
HY-164496 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-164496
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medchemexpress.com/kl-50.html
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Catalog No: HY-164496
CAS No: 1161826-19-2
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase MGMT , which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair MMR . KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT.
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