GENERAL CATALOGUE
KNT-127
HY-120511 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-120511
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medchemexpress.com/knt-127.htmlCatalog No: HY-120511
CAS No: 1256921-89-7
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
KNT-127 is a selective and BBB-penetrant ?-opioid receptor DOR agonist Ki = 0.16 nM . KNT-127 is highly selective to the ? receptor, with Ki values of 0.16, 21.3 and 153 nM for ?, ? and ? receptors, respectively. KNT-127 acts as a biased ligand that mainly activates cyclic adenosine monophosphate cAMP signaling with lower beta-arrestin signaling activation. KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens, and prefrontal cortex. KNT-127 exhibits antidepressant- and anxiolytic-like effects. KNT-127 can be studied in research on neurological diseases.
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