KO-Validated ACTN1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KO-Validated ACTN1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000 Alternative Names of Immunogen:ACTN1; Actinin Alpha 1; F-Actin Cross-Linking Protein; Non-Muscle Alpha-Actinin-1; Alpha-Actinin-1; Epididymis Secretory Sperm Binding Protein; Alpha-Actinin Cytoskeletal Isoform; Actinin 1 Smooth Muscle; BDPLT15 Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Research Area: Signal Transduction,Stem Cells,Developmental Biology