KO-Validated BAP1 Recombinant Rabbit Monoclonal Antibody

Description

EnkiLife offers the KO-Validated BAP1 Recombinant Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat and is suitable for WB application. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1,000-1:5,000 Alternative Names of Immunogen:BAP1; BRCA1 Associated Protein 1; KIAA0272; Hucep-6; UCHL2; BRCA1 Associated Protein-1 (Ubiquitin Carboxy-Terminal Hydrolase); Ubiquitin Carboxyl-Terminal Hydrolase BAP1; Cerebral Protein 6; Ubiquitin Carboxy-Terminal Hydrolase; BRCA1-Associated Protein 1; Cerebral Protein-13; EC 3.4.19.12; HUCEP-13; KURIS; TPDS1; UBM2; UVM2 Background: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013] Research Area: Cell Biology,Epigenetics and Nuclear Signaling,Cancer